Zondag 11 oktober
| Heerenveen | – | Nieuw Buinen | 4-0 |
| SC Erica | – | TEVV | 2-2 |
| Amicitia VMC | – | Titan | 3-2 |
| Peize | – | Valthermond | 1-1 |
| Musselkanaal | – | Raptim | 1-0 |
| Ter Apel ‘96 | – | SVV ‘04 | 5-2 |
| Sleen | – | SC Stadskanaal | 2-1 |
| Gieten | – | Twedo | 8-1 |
| Meeden | – | Alteveer | 0-2 |
| Pekelder Boys | – | Eenrum | 3-0 |
| Westerwolde | – | Nieuw Roden | 4-3 |
| WEO | – | Sellingen | 2-1 |
| SPW | – | JVV | 3-1 |
| Gasselternijveen | – | BNC | 0-1 |
| Buinerveen | – | VIOS O | 0-7 |
| HOC | – | Buinen | 7-1 |
| EEC | – | DOS ‘63 | 2-1 |
| Eext | – | GKC | 3-2 |
| Zandpol | – | Gieterveen | 0-4 |
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