Uitslagen zondag 25 september
| LSC 1890 | – | Nieuw Buinen | 1-2 |
| ZNC | – | Valthermond | 1-3 |
| Gieten | – | Ter Apel ‘96 | 2-0 |
| Musselkanaal | – | Sleen | 0-4 |
| SVV ‘04 | – | SC Stadskanaal | 1-0 |
| Asser Boys | – | Titan | 3-0 |
| Alteveer | – | Zuidlaarderveen | 2-0 |
| Pekelder Boys | – | FVV | 1-3 |
| Westerwolde | – | Gieterveen | 5-2 |
| HOC | – | Weerdinge | 1-2 |
| Sellingen | – | SVBC | 4-1 |
| Buinen | – | De Treffer ‘16 | 2-0 |
| Eext | – | Buinerveen | 2-1 |
| VIOS O | – | EEC | 1-1 |
| Weiteveense Boys | – | GKC | 13-0 |
| Valther Boys | – | Gasselternijveen | 3-0 |
| Drieborg | – | JVV | 7-1 |
| SPW | – | DWZ | 4-0 |
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